Factors associated with heterogeneity in microarray gene expression in peripheral blood mononuclear cells from large pedigrees

Table 1 Association of pedigree number with PC1, PC2, proportions of cytotoxic and helper T cells

Pedigree number	# members	PC1			PC2			Cytotoxic T cells			Helper T cells
Pedigree number	# members	B	SE	P	B	SE	P	B	SE	P	B	SE	P
2	67	−15.3	6.1	0.013	−6.3	3.6	0.083	−4.6 e-3	5.2 e-3	0.37	7.7e-3	5.1 e-3	0.14
3	44	−10.7	7.5	0.16	−3.9	4.5	0.39	−1.8 e-2	5.9 e-3	0.0021	2.0e-2	5.8 e-3	6.6e-4
4	39	8.7	8.0	0.28	14.9	4.7	0.0018	−1.0 e-2	6.3 e-3	0.12	9.5e-3	6.2 e-3	0.13
5	55	−0.4	6.7	0.94	−18.4	4.0	5.6e-6	−1.6 e-2	5.7 e-3	0.0046	1.7e-2	5.6 e-3	0.0022
6	45	1.6	7.4	0.83	−14.9	4.4	8.6e-4	−1.4 e-2	6.0 e-3	0.019	1.4e-2	6.0 e-3	0.015
8	62	−1.5	6.3	0.81	33.8	3.7	<2e-16	1.3 e-3	5.6 e-3	0.81	−2.5e-3	5.5e-3	0.64
10	49	−6.8	7.1	0.34	−4.8	4.2	0.26	−6.4 e-3	5.6 e-3	0.26	6.5e-3	5.6e-3	0.24
14	30	−10.5	9.1	0.25	2.9	5.4	0.59	−1.6 e-2	6.7 e-3	0.015	1.5e-2	6.6e-3	0.019
15	27	17.1	9.6	0.076	3.0	5.7	0.59	−1.8 e-2	7.0 e-3	0.0086	1.6 e-2	6.9 e-3	0.019
16	38	−4.3	8.1	0.60	−3.6	4.8	0.45	−2.9 e-3	6.1 e-3	0.63	3.3 e-3	6.0 e-3	0.58
17	29	8.6	9.3	0.36	4.2	5.5	0.44	−6.7 e-3	6.7 e-3	0.32	1.3 e-3	6.6 e-3	0.84
20	26	−1.6	9.8	0.86	−7.9	5.8	0.18	7.0 e-4	7.2 e-3	0.92	7.4 e-4	7.1 e-3	0.92
21	30	2.5	9.1	0.78	2.5	5.4	0.63	−1.1 e-2	6.7 e-3	0.084	9.5 e-3	6.6 e-3	0.15
23	28	4.4	9.5	0.64	−13.3	5.6	0.018	1.0 e-3	6.8 e-3	0.88	7.5 e-3	6.7 e-3	0.27
25	22	4.9	10.7	0.65	−4.1	6.3	0.52	5.3 e-3	7.6 e-3	0.48	−3.4 e-4	7.4 e-3	0.96
27	31	24.1	9.0	0.0076	15.0	5.3	0.0051	−2.6 e-2	6.5 e-3	6.2e-5	2.0 e-2	6.4 e-3	0.0013
47	21	13.9	10.9	0.20	−9.1	6.5	0.16	−9.2 e-3	7.8 e-3	0.24	2.4 e-2	7.7 e-3	0.0019

Three pedigrees (7, 9, and 11) had no individuals with gene expression data. Global p = 0.091 for PC1, p < 2.2e-16 for PC2, p = 6.5e-12 for cytotoxic T-cell proportion, and p = 8.5e-9 for helper T-cell proportion. Bold indicates pedigrees with significant differences at α = 0.05/17(pedigrees) level (p < 0.0029)

ISSN: 1753-6561