Table 3 Raw and adjusted p values of the top genes identified by SKAT and SKAT-O and the minimum of the adjusted p values for variants in the gene under the copula model, obtained from testing H 0 : β 1 = 0 for GE
From: Genetic association analysis based on a joint model of gene expression and blood pressure
Gene | SKAT/SKAT-O | Copula | ||
|---|---|---|---|---|
p value | Adjusted p value | p value | Adjusted p value | |
UBA52 | 1.36 × 10− 12 | 1.15 × 10− 09 | 6.47 × 10− 60 | 1.71 × 10− 55 |
IGFLR1 | 3.79 × 10− 10 | 1.61 × 10− 07 | 3.74 × 10− 19 | 1.24 × 10− 15 |
ACP5 | 3.12 × 10− 09 | 8.83 × 10− 07 | 4.95 × 10− 12 | 5.33 × 10− 09 |
CNN2 | 4.96 × 10− 07 | 9.06 × 10− 05 | 2.01 × 10− 14 | 3.56 × 10− 11 |
ANKRD27 | 5.34 × 10− 07 | 9.06 × 10− 05 | 6.08 × 10− 13 | 7.94 × 10− 10 |