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Table 3 Significant and consistent estimates of disease locus positions and their genetic effects using “Baseline” and “Longitudinal” phenotypes

From: Multipoint association mapping for longitudinal family data: an application to hypertension phenotypes

Gene*

Baseline

Longitudinal

Previous hits

\( \widehat{\tau} \) ± SE

Ĉ

p Value

\( \widehat{\tau} \) ± SE

Ĉ

p Value

GRM7†

7.4917 ± 0.00048

0.44

2.87 × 10−5

7.4871 ± 0.0015

0.75

6.04 × 10−14

LG

SLC4A7

27.4521 ± 0.000045

0.30

0.014

27.4520 ± 0.000067

0.30

0.0024

LG

SCN10A

38.7559 ± 0.0089

0.088

0.019

38.7611 ± 0.0018

0.73

0.0022

 

AC092058.3

39.5105 ± 0.0020

0.076

0.036

39.5102 ± 0.00024

0.21

0.00022

 

LTF

46.4731 ± 0.00059

0.17

0.046

46.4733 ± 0.00045

0.31

0.0099

 

NEK4

52.7326 ± 0.00071

0.83

0.00010

52.7277 ± 0.0024

0.86

0.00024

 

FAM116A

57.6101 ± 0.00023

0.69

2.58 × 10−6

57.6107 ± 0.00032

0.61

0.011

 

LRIG1

66.5968 ± 0.0026

0.28

0.018

66.5961 ± 0.00064

0.60

0.0022

L

TBC1D23

101.5084 ± 0.0011

0.46

0.026

101.5148 ± 0.0010

0.73

0.0011

L

ALCAM

106.7625 ± 0.00069

0.83

0.028

106.7598 ± 0.00041

0.62

0.00013

L

PLCXD2

112.9440 ± 0.00087

0.50

0.0016

112.9422 ± 0.0062

0.48

0.00020

L

LSAMP

117.0676 ± 0.00060

0.43

0.00022

117.0671 ± 0.00025

0.86

0.00012

L

ILDR1

123.2009 ± 0.0011

0.70

0.013

123.2008 ± 0.00098

0.91

0.023

 

PDIA5

124.3194 ± 0.0076

0.065

0.0028

124.3225 ± 0.0020

0.68

0.0086

 

HPS3

150.3484 ± 0.0016

0.14

1.65 × 10−5

150.3521 ± 0.00063

0.77

0.0080

L

CASRL1

157.2304 ± 0.0037

0.19

0.012

157.2295 ± 0.00094

0.28

0.031

L

C3orf55

158.7595 ± 0.00074

0.90

0.0051

158.7634 ± 0.0012

0.91

3.90 × 10−6

L

IGF2BP2

186.9725 ± 0.00018

0.74

0.041

186.9719 ± 0.00031

1.00

0.031

 

FETUB ‡

187.8470 ± 0.00031

0.38

0.0012

187.8503 ± 0.017

0.042

0.0021

 

IL1RAP ‡

191.8193 ± 0.012

0.074

0.0060

191.8203 ± 0.0012

0.79

4.75 × 10−6

 

C3orf21 ‡

196.2815 ± 0.0036

0.62

<10−18

196.2821 ± 0.0011

0.97

0.00057

 

KIAA0226

198.9161 ± 0.0038

0.071

0.024

198.9168 ± 0.00076

0.15

0.022

 
  1. Ĉ, the genetic effect estimate; G, previous GWAS hits; L, previous linkage hits; \( \widehat{\tau} \), the disease locus position estimate in cM
  2. *Displayed are all genes where p ≤ 0.05
  3. †The gene is significant with the Bonferroni correction (P < 4.57 × 10−5) and its P values are 2.31 × 10−6 and 0.00044 for “Ever” and “Progression,” respectively
  4. ‡ The same genes for the “Ever” and “Progression” phenotypes had P values <0.05 but > 4.57 × 10−5 for the genetic effect estimate
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BMC Proceedings

ISSN: 1753-6561

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