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Table 2 Significant haplotypes on ULK4 gene by haplo.glm or haplo.score (in addition to those indicated in Table 1)

From: Association of rare haplotypes on ULK4 and MAP4 genes with hypertension

SNP# in haplotype block

Location

Hap name

Hap freq

LBL (OR)

LBL (BF)

Haplo GLM (p value)

Haplo score (p value)

Haplo score overall test (p value)

8–12

41497115–41657184

00001

0.0014

2.471

1.430

0.040*

0.010*

0.005*

9–13

41504594–41722969

00010

0.0016

2.022

1.123

0.035*

0.016*

0.005*

10–14

41504679–41722976

00100

0.0016

2.155

1.050

0.036*

0.016*

0.064

00001

0.0019

0.218

1.743

0.000*

0.130

0.064

11–15

41607541–41723054

01000

0.0016

2.118

1.394

0.037*

0.016*

0.085

00001

0.0011

0.305

1.151

0.000*

0.252

0.085

12–16

41657184–41723090

10000

0.0016

2.137

1.281

0.036*

0.016*

0.041*

00010

0.0011

0.307

1.278

0.000*

0.252

0.041*

00100

0.0019

0.226

1.773

0.000*

0.130

0.041*

26–30

41796016–41841618

00001

0.0033

2.036

1.340

0.047*

0.040*

0.331

10000

0.0016

0.286

1.355

0.000*

0.161

0.331

27–31

41796025–41841716

00010

0.0032

1.945

1.051

0.045*

0.040*

0.565

28–32

41831203–41841811

00100

0.0032

1.900

0.989

0.047*

0.040*

0.357

00001

0.0018

0.248

1.595

0.000*

0.132

0.357

30–34

41841618–41861013

10000

0.0030

1.877

1.036

0.039*

0.046*

0.649

01001

0.0016

0.565

0.737

0.000*

0.487

0.649

39–43

41925423–41939990

01010

0.0012

0.555

0.809

0.000*

0.543

0.219

40–44

41937000–41939992

10010

0.0016

0.821

0.798

0.000*

0.495

0.253

10100

0.0012

0.606

0.791

0.000*

0.549

0.253

44–48

41939992–41949348

01001

0.0004

2.228

1.270

NA

0.000*

1.000

10001

0.0010

1.813

0.915

0.000*

0.104

1.000

47–51

41949301–41952774

00001

0.0048

1.881

1.407

0.046*

0.043*

0.000*

48–52

41949348–41952781

00010

0.0048

1.842

1.252

0.049*

0.040*

0.011*

49–53

41949359–41952838

00100

0.0048

1.900

1.293

0.049*

0.040*

0.161

50–54

41949479–41952852

01000

0.0047

2.000

1.449

0.032*

0.037*

0.299

51–55

41952774–41952898

10000

0.0045

2.163

1.838

0.023*

0.023*

0.218

  1. Major allele is coded as 0. SNP# corresponds to the order of SNP in the gene among SNPs with MAF ≥0.001 and no more than 25 % missing genotypes. The blocks shown in bold in the first column are reported in Table 1 also but for a different haplotype
  2. Hap haplotype, Hap freq haplotype frequency (obtained from hapassoc); NA, this haplotype was not returned by haplo.glm as its frequency is below pooling tolerance of 0.001
  3. *Significant p value
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BMC Proceedings

ISSN: 1753-6561

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