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Fig. 1 | BMC Proceedings

Fig. 1

From: The vitamin D paradox in Black Americans: a systems-based approach to investigating clinical practice, research, and public health - expert panel meeting report

Fig. 1

Vitamin D Pathways: An Overview (source: Nutrients 2016, 8, 319) [6]. The conversion of vitamin D to the active metabolite, 1,25(OH)2D, is shown. The pathway starts with the exposure of vitamin D from dietary sources or via cutaneous synthesis following UVB radiation. Vitamin D is bound to VDBP and transported to the liver where it is converted to 25(OH)D, the current biomarker for vitamin D status. PTH enhances 1-alpha hydroxylase in the kidneys which is responsible for the conversion of the inactive metabolite, 25(OH)D, to the active metabolite, 1,25(OH)2D. The entire pathway is tightly regulated via catabolic and feedback loop processes as shown

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