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Table 2 MR results with CIV and TSLS at RNMT;C18orf19 and C6orf141 using the SNP sets F and R

From: Investigating potential causal relationships between SNPs, DNA methylation and HDL

Gene

# SNPs selected by CIV

Instrument strength of CIV: F-stat/CP a

Instrument strength of TSLS: F-stat/CP a

#Associated probes by CIV b (# also naïve)

#Associated probes by TSLS c (# also naïve)

RNMT;C18orf19

1

22.83/22.96

(F) 2.21/346.03

(R) 8.88/136.39

1(1)

1(1)

C6orf141

11

1.42/27.81

(F) 1.35/78.01

(R) 1.12/23.01

3(1)

1(1)

  1. The number of associated probes based on 95% bootstrap confidence intervals is shown, and the instrument strength at the most strongly associated CpG is also reported. Egger regression with SNP set F only identified the probe in C6orf141.
  2. a F-stat/CP,F-statistic/concentration parameter
  3. b Number of CpGs showing significant MR association with CIV (number of these probes also demonstrating naïve association)
  4. c TSLS has the same result using set F or set R
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BMC Proceedings

ISSN: 1753-6561

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