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Table 1 (abstract P-160). Scalability of production of bsAb from a small scale vessel to a large production process

From: Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients

Vessel

Titer (g/L)a

Purity (%)b

AA

AB

BB

Spin Tube

4.9

1.4

92.7

5.9

Shake Flask

4.2

0.7

95.5

3.8

Ambr15

5.6

0.6

96.5

2.9

Ambr250

4.9

1.0

93.5

4.9

Bioreactor

4.9

1.1

97.6

1.6

  1. a total protein HPLC titer (homodimers + heterodimer). Representative of up to 6 different clone samples
  2. b homodimer (AA, BB) versus heterodimer (AB) purity determined by μCE-SDS. Representative of up to 4 clone sample repeats.
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BMC Proceedings

ISSN: 1753-6561

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