Volume 2 Supplement 1

Infectious diseases of the nervous system: pathogenesis and worldwide impact

Open Access

Distal peripheral neuropathy in HIV-infected children

  • Peggy Martínez Esteban1Email author,
  • Joseph R Zunt2,
  • Silvia Montano Torres3,
  • Julio Flores Bravo4,
  • Lenka Kolevic Roca5 and
  • Nicanor Mori Quispe6
BMC Proceedings20082(Suppl 1):P37

https://doi.org/10.1186/1753-6561-2-s1-p37

Published: 23 September 2008

Background

Distal symmetric peripheral neuropathy (DSPN) is the most common form of peripheral neuropathy in HIV-infected children, but little is known about its prevalence in HIV-infected children living in the developing world. The aims were to determine the frequency of symptoms, signs and risk factors for DSPN in HIV-infected children living in Peru.

Methods

Cross sectional study of children older than 18 months attending the Instituto Nacional de Salud Del Niño. Medical records were reviewed to obtain information regarding HIV infection and treatment. Patients older than 5 years old completed a standardized questionnaire regarding neuropathic symptoms. All subjects underwent detailed neurologic examination and nerve conduction study. Presence of DSPN was defined according to guidelines of the American Academy of Neurology, American Academy of Electrodiagnostic Medicine, American Association or Physical Medicine & Rehabilitation [1].

Results

90 subjects were enrolled. Age ranged from 18 months to 18 years. 12 patients (13.3%) had DSPN, with diminished ankle jerks and paresthesias the most common clinical findings. In 84 (93.3%) subjects HIV infections was acquired vertically, 76 (84.4%) were on antiretroviral treatment, and 51 (56.7%) were at C3 CDC classification. Malnutrition was associated with presence of DSPN (OR 12.82; IC 95% 1.14–144.42). Duration of HIV infection, viral load, CD4 count and antiretroviral treatment were not associated with presence of DSPN.

Conclusion

Distal symmetric polyneuropathy was present in 13.3% of HIV-infected children and was associated with malnutrition. Future longitudinal studies could examine other risk factors associated with DSPN in HIV-infected children.

Authors’ Affiliations

(1)
Department of Neurophysiology, Instituto Nacional de Ciencias Neurológicas
(2)
Deptartments of Neurology, Global Health and Medicine (Infectious Diseases), University of Washington
(3)
US Naval Medical Research Center Detachment
(4)
Department of Neuropediatrics, Instituto Nacional de Salud del Niño
(5)
Department of Infectious Diseases, Instituto Nacional de Salud del Niño
(6)
Universidad Nacional Mayor de San Marcos

References

  1. England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT, Cohen JA, Fisher MA, Howard JF, Kinsella LJ, Latov N, Lewis RA, Low PA, Sumner AJ: Distal symmetric polyneuropathy: A definition for clinical research. Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2005, 64: 199-207.View ArticlePubMedGoogle Scholar

Copyright

© Esteban et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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