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Anti-epileptic properties of oleamide
© Mikautadze et al; licensee BioMed Central Ltd. 2008
Published: 23 September 2008
Epilepsy is a heterogeneous group of disorders. It is the most common neurological disorder after the stroke, with a 2–3% life-time risk of being given a diagnosis of epilepsy . Antiepileptogenic drugs that retard or prevent epileptogenesis are not yet available . Extract of the plant Aquilegia vulgaris is widely used in folk medicine as an antiepileptic medicament . We have previously demonstrated that oleamid – sleep inducing lipid and myo-inositol are two compounds acting on γ-aminobuturic acid type A receptors and hence candidates determining the anti-epileptic properties of the plant Aquilegia vulgaris . Further it was shown that myo-inositol reduces the strength of seizures induced either by pentylentetrazol or kainic acid in rats. In the present work we are demonstrating that oleamid also posseses anti-epileptic features and significantly decreases the degrees of convulsions induced by pentylentetrazole in rats.
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