Volume 2 Supplement 1

Infectious diseases of the nervous system: pathogenesis and worldwide impact

Open Access

Anti-epileptic properties of oleamide

  • Ekaterine Mikautadze1Email author,
  • Natalia Avaliani1,
  • Nino Kuchiashvili2,
  • Maia Nozadze2,
  • Tamar Kiguradze2,
  • Victoria Pkhakadze2,
  • Irina Mamulaishvili2,
  • Eka Mikeladze2 and
  • Revaz Solomonia1, 2
BMC Proceedings20082(Suppl 1):P42

https://doi.org/10.1186/1753-6561-2-s1-p42

Published: 23 September 2008

Epilepsy is a heterogeneous group of disorders. It is the most common neurological disorder after the stroke, with a 2–3% life-time risk of being given a diagnosis of epilepsy [1]. Antiepileptogenic drugs that retard or prevent epileptogenesis are not yet available [2]. Extract of the plant Aquilegia vulgaris is widely used in folk medicine as an antiepileptic medicament [3]. We have previously demonstrated that oleamid – sleep inducing lipid and myo-inositol are two compounds acting on γ-aminobuturic acid type A receptors and hence candidates determining the anti-epileptic properties of the plant Aquilegia vulgaris [4]. Further it was shown that myo-inositol reduces the strength of seizures induced either by pentylentetrazol or kainic acid in rats. In the present work we are demonstrating that oleamid also posseses anti-epileptic features and significantly decreases the degrees of convulsions induced by pentylentetrazole in rats.

Authors’ Affiliations

(1)
Faculty of Life Sciences, I. Chavchavadze Tbilisi State University
(2)
Department of Biochemistry, I. Beritashvili Institute of Physiology

References

  1. Browne TR, Holmes GL: Epilepsy. N Engl J Med. 2001, 344: 1145-1151. 10.1056/NEJM200104123441507.View ArticlePubMedGoogle Scholar
  2. Loscher W: Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Research. 2002, 50: 105-123. 10.1016/S0920-1211(02)00073-6.View ArticlePubMedGoogle Scholar
  3. Shreter AI: Medicinal Herbs of Soviet Far East. 1975, Moscow: Medicina, 105-106.Google Scholar
  4. Solomonia R, Kuchiashvili N, Berulava A, Pkhakadze V, Trapaidze N, Zhvania M, Abesadze I, Kojima H, Dalakishvili N: Purification and identification of components of the Aquilegia vulgaris extract fraction exhibiting anti-epileptic activity. J Biol Phys Chem. 2004, 4: 187-192.Google Scholar

Copyright

© Mikautadze et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Advertisement