Skip to content


BMC Proceedings

Open Access

Primary bone lymphoma

  • C Pissarro C Azevedo1Email author,
  • P José AFF Tavares2,
  • M Isabel P Portela1,
  • A José LCP Santos2 and
  • J Manuel PS Casanova2
BMC Proceedings20104(Suppl 2):P8

Published: 24 September 2010


Survival RateLymphomaHistological TypeRetrospective ReviewGood Survival


Primary bone lymphoma (PBL) accounts for 3% of all primary bone malignancies [1] and represents <2% of all lymphomas in adults [2].

Material and methods

Retrospective review of 25 patients with PBL treated at a single institution between 1995 and 2010.


14 patients were female. The median age was 63 years (30-90). 13 had localized disease. The tumor had an axial location in 20 patients (80%). 6 patients presented with a pathologic fracture. The histological type was Non-Hodgkin Lymphoma B in all patients. There were 18 high grade lymphomas. According to the IPI, 8 cases (32%) were classified as low risk, 11 cases (44%) as intermediate risk and 6 (24%) as high risk. All patients received chemotherapy. 17 patients were treated with radiotherapy to a total dose that varied from 15 to 50 Gy. 7 patients underwent surgical treatment. The median follow-up was 12 months (1-121). Recurrence of the disease was seen in 3 patients. 9 patients had disease progression. With regard to the status of the patients: 8 patients are continuously disease free; 3 patients are alive with disease; 10 patients died of the disease; 2 patients died of other cause. The 10-year overall survival rate was 45%. The 5-year survival rate was 85% for low-risk IPI vs 35% for intermediate-risk IPI vs 18% for high-risk IPI.


Combined modality treatment results in good survival rates in patients with low-risk and intermediate-risk PBL.

Authors’ Affiliations

Department of Medical Oncology, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal
Bone and Soft Tissue Tumor Unit, Coimbra University Hospital, Coimbra, Portugal


  1. Limb D, Dreghorn C, Murphy JK, Mannion R: Primary lymphoma of bone. Int Orthop. 1994, 18: 180-183. 10.1007/BF00192476.View ArticlePubMedGoogle Scholar
  2. Dubey P, Ha CS, Besa PC, Fuller L, Cabanillas F, Murray J, Hess MA, Cox JD: Localized primary malignant lymphoma of bone. Int J Radiat Oncol Biol Phys. 1997, 37: 1087-1093. 10.1016/S0360-3016(97)00106-5.View ArticlePubMedGoogle Scholar


© Azevedo et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.