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  • Open Access

A transgenic mouse model for studying HBV infection in neonate

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  • 1 and
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BMC Proceedings20115 (Suppl 1) :P23

https://doi.org/10.1186/1753-6561-5-S1-P23

  • Published:

Keywords

  • Transgenic Mouse
  • Surface Antigen
  • Mouse Liver
  • Transgenic Mouse Model
  • Envelope Protein

The human hepatitis B virus (HBV) infection is always a worldwide problem, especially the high risk infection of the neonate by chronically HBV infected mother. McGrane et al. [1] have demonstrated that the gene which is driven by the promoter of phosphoenolpyruvate carboxykinase (PEPCK) is mainly expressed in the mouse liver and immediately appears at parturition. We have constructed a transgenic mouse by using PEPCK promoter to drive the pre-S2 and S domain of HBV envelope protein to imitate HBV transmission from mother to child. We want to see whether hepatitis B surface antigen (HBsAg) can persistently exist or be cleared by immune system from the newborn mice.

Authors’ Affiliations

(1)
Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200025, PR China

References

  1. McGrane MM, Yun JS, Moorman AF, et al: Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice. J Biol Chem. 1990, 265: 22371-22379.PubMedGoogle Scholar

Copyright

© Wang et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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