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A transgenic mouse model for studying HBV infection in neonate

The human hepatitis B virus (HBV) infection is always a worldwide problem, especially the high risk infection of the neonate by chronically HBV infected mother. McGrane et al. [1] have demonstrated that the gene which is driven by the promoter of phosphoenolpyruvate carboxykinase (PEPCK) is mainly expressed in the mouse liver and immediately appears at parturition. We have constructed a transgenic mouse by using PEPCK promoter to drive the pre-S2 and S domain of HBV envelope protein to imitate HBV transmission from mother to child. We want to see whether hepatitis B surface antigen (HBsAg) can persistently exist or be cleared by immune system from the newborn mice.


  1. McGrane MM, Yun JS, Moorman AF, et al: Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice. J Biol Chem. 1990, 265: 22371-22379.

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Wang, Z., Deng, Q. & Lan, K. A transgenic mouse model for studying HBV infection in neonate. BMC Proc 5 (Suppl 1), P23 (2011).

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