Skip to main content

A transgenic mouse model for studying HBV infection in neonate

The human hepatitis B virus (HBV) infection is always a worldwide problem, especially the high risk infection of the neonate by chronically HBV infected mother. McGrane et al. [1] have demonstrated that the gene which is driven by the promoter of phosphoenolpyruvate carboxykinase (PEPCK) is mainly expressed in the mouse liver and immediately appears at parturition. We have constructed a transgenic mouse by using PEPCK promoter to drive the pre-S2 and S domain of HBV envelope protein to imitate HBV transmission from mother to child. We want to see whether hepatitis B surface antigen (HBsAg) can persistently exist or be cleared by immune system from the newborn mice.

References

  1. McGrane MM, Yun JS, Moorman AF, et al: Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice. J Biol Chem. 1990, 265: 22371-22379.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Wang, Z., Deng, Q. & Lan, K. A transgenic mouse model for studying HBV infection in neonate. BMC Proc 5, P23 (2011). https://doi.org/10.1186/1753-6561-5-S1-P23

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/1753-6561-5-S1-P23

Keywords

  • Transgenic Mouse
  • Surface Antigen
  • Mouse Liver
  • Transgenic Mouse Model
  • Envelope Protein