- Poster presentation
- Open Access
A transgenic mouse model for studying HBV infection in neonate
BMC Proceedings volume 5, Article number: P23 (2011)
The human hepatitis B virus (HBV) infection is always a worldwide problem, especially the high risk infection of the neonate by chronically HBV infected mother. McGrane et al.  have demonstrated that the gene which is driven by the promoter of phosphoenolpyruvate carboxykinase (PEPCK) is mainly expressed in the mouse liver and immediately appears at parturition. We have constructed a transgenic mouse by using PEPCK promoter to drive the pre-S2 and S domain of HBV envelope protein to imitate HBV transmission from mother to child. We want to see whether hepatitis B surface antigen (HBsAg) can persistently exist or be cleared by immune system from the newborn mice.
McGrane MM, Yun JS, Moorman AF, et al: Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice. J Biol Chem. 1990, 265: 22371-22379.
About this article
Cite this article
Wang, Z., Deng, Q. & Lan, K. A transgenic mouse model for studying HBV infection in neonate. BMC Proc 5, P23 (2011). https://doi.org/10.1186/1753-6561-5-S1-P23
- Transgenic Mouse
- Surface Antigen
- Mouse Liver
- Transgenic Mouse Model
- Envelope Protein