Stem cell: from basic theoretical assumptions and mathematical concepts to the computational models
© Simeonova and Milanova; licensee BioMed Central Ltd. 2011
Published: 22 November 2011
Stem cells (SC) and their therapeutic applications have a great promise for treatment of many human diseases, . Characteristics of Embryonic Stem Cells (ESC) have been presented in . The aim of the paper presented has been formulated as follows: to give some classical mechanics and mathematics theories for SC studies. Mathematical models for cancer diseases and neurological disorders have been discussed too.
Materials and methods
Models, including a viscoelastic continuum, a combination of viscoelastic fluid have been developed as well, . By relatively modern (for that time) microscopic techniques, developed during the eighteenth have been observed the images of living cells. Later using imaging mechanics, have been discovered AFM, imaging for study of living cells. High resolution of AFM imaging “has provided information on the structure. It has been proved as well,  that blood, blood vessels and nerves, could be tested mechanically.
Mathematical models of SC for neuroscience
Theoretical concepts and mathematical models have been proposed for explanation quantitatively biological mechanisms. Mechanisms and models of cellular State Transition have been discussed too. Other periodic hematological diseases involve oscillations in all of the blood cells. In the paper , has been developed a simple mathematical model0. The probabilities for CSC to reach levels, compatible with the diagnosis of acute leukemia, by CSC, as well as probability for extinction have been computed analytically.
An analytical model
A computational model, results
Future problems and current studies on SC are: SC is very promising tool for various biopharm applications, Future technologies will be enabled fuller understanding of SC, Future directions for human S Cell Culture optimization, ES could be used as vechile for gene therapy.
We thank you to Professor Nicole Borth, and to Organizers of ESACT2011, for their great cooperation to attend ESACT Meeting in Vienna, 15-18 May, 2011 and to present both poster reports.
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