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  • Keynote lecture presentation
  • Open Access

Integrative cancer informatics for the identification of prognostic and predictive biomarkers

BMC Proceedings20137 (Suppl 2) :K7

  • Published:


  • Regulatory Network
  • Drug Combination
  • Gene Interaction
  • Molecular Signature
  • Integrative Analysis

Cancer development is a multi-step process that leads to uncontrolled tumor cell growth. Multiple pathways are involved; typically some signalling and regulatory pathways are activated, while others are suppressed. Systematically exploring these networks of proteins will lead to better understanding of disease initiation and progression. Integrating these data with microRNA regulatory networks may identify control mechanism that these master regulators use to affect oncogenesis. Including data on drug targets, modes of actions predicted from drug profiles and compound similarity will in turn lead to more effective patient treatment. To address these challenges, we developed a system for an integrative analysis, prediction and characterization of molecular signatures and relevant protein-protein interactions, microRNA: gene interactions, and resources for rationally identifying drug combinations for cancer treatment.


Authors’ Affiliations

Ontario Cancer Institute and University Health Network, University of Toronto, Canada


© Jurisica; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.