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Implementation of a quality by design approach into cell line and process development for recombinant protein production

Authors: Caroline Noack, Anne Schüler and Markus Wieland

Citation: BMC Proceedings 2015 9(Suppl 9):P79

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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A method to determine and simulate the permeation through a gel matrix in a multi-organ-chip

Authors: Hao-Hsiang Hsu, Laura E Harder, Gerd Lindner, Uwe Marx and Ralf Pörtner

Citation: BMC Proceedings 2015 9(Suppl 9):P77

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Phase I clinical trials of safety and immunogenicity of live cultural influenza vaccine vector-flu

Authors: Elena A Nechaeva, Marina P Bogryantseva, Alexander B Ryzhikov, Ol'ga G P'yankova, Tatyana Y Sen'kina, Irina F Radaeva, Sergey Y Nechaev, Natalya I Ryndyuk, Vladimir I Kuzubov, Zoya I Gin'ko, Irina V Kiseleva and Larisa G Rudenko

Citation: BMC Proceedings 2015 9(Suppl 9):P73

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Generation of novel microcarrier for expansion of human mesenchymal stem cells

Authors: Dave Splan, Grishma Patel, Heather Woolls and Mark Szczypka

Citation: BMC Proceedings 2015 9(Suppl 9):P71

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Intracellular trafficking pathways for plasmid DNA complexed with highly efficient endosome escape polymers

Authors: Marianne Gillard, Zhongfan Jia, Jeff Hou, Michael Song, Peter P Gray, Trent P Munro and Michael J Monteiro

Citation: BMC Proceedings 2015 9(Suppl 9):P69

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Ex vivo production of red blood cells from human cord blood

Authors: Marta Caminal, Juan P Labrozzi, Irene Oliver-Vila, Martí Alzaga-Gragera, Silvia Marín-Gallén, Arnau Pla, Joan García and Joaquim Vives

Citation: BMC Proceedings 2015 9(Suppl 9):P67

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Off-the-shelf mesenchymal stromal cells derived from umbilical cord tissue

Authors: Irene Oliver-Vila, Maria I Coca, Marta Grau-Vorster, Noelia Pujals-Fonts, Marta Caminal, Arnau Pla, Joan García and Joaquim Vives

Citation: BMC Proceedings 2015 9(Suppl 9):P65

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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A New Integrated Knowledge Management & Data Analysis Platform for Cell Line Development & Cell Culture R&D

Authors: Jens Niklas, Julia Retey, Steffen Fehrmann, Ludwig Macko, Thomas Hartsch and Ben Adamczyk

Citation: BMC Proceedings 2015 9(Suppl 9):P63

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Comparison of CHO cell cultivation and mAbproduction in the Allegro™ XRS 20 and conventional rocker type single-use bioreactors

Authors: Gail Henry, Byron Rees and Charles Golightly

Citation: BMC Proceedings 2015 9(Suppl 9):P59

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Media and microcarrier surface must be optimized when transitioning mesenchymal stem/stromal cell expansion to stirred tank bioreactors

Authors: Aletta Schnitzler, Anjali Verma, Manjula Aysola, Julie Murrell and Martha Rook

Citation: BMC Proceedings 2015 9(Suppl 9):P57

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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A Simplified implementation of the O.U.R. stationary liquid mass balance estimation method for On-line monitoring in Animal cell production processes

Authors: Andreu Fontova, Jonatan López-Repullo, Martí Lecina, Ramon Bragós and Jordi J Cairó

Citation: BMC Proceedings 2015 9(Suppl 9):P56

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Chemically modified cysteine in CHO fed-batch processes and impact on the specific productivity

Authors: Caroline Hecklau, Ronja Seibel, Maria Wehsling, Jennifer Kuschelewski and Aline Zimmer

Citation: BMC Proceedings 2015 9(Suppl 9):P55

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Manufacturing ultra-concentrated liquid feeds: Transitioning the aqueous solubility barrier of the feed amino acids cysteine and tyrosine

Authors: Claudia Knack, Caroline Zessel, Christian Schultheiß, Doris Matheis, Christian Schild, Jörg von Hagen, Michael Rayner and Jochen Sieck

Citation: BMC Proceedings 2015 9(Suppl 9):P54

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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CHO-DHFR cell line development platform: Application of Clonepix and Automated Mini Bioreactor (AMBR) technologies to meet accelerated timelines

Authors: Venkata R Mangalampalli, Dyane Wycuff, Mingzhong Chen, David Berlinger, Elizabeth H Scheideman, Amritha Menon, Guilia Fabozzi, Althaf Hussain and Richard M Schwartz

Citation: BMC Proceedings 2015 9(Suppl 9):P52

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Synthetic peptide matrices as support for stem cells culture

Authors: Youlia Serikova, Martin Bousmanne, Jean-Christophe Drugmand, Marc Fouassier, Laurent Jeannin and Yves-Jacques Schneider

Citation: BMC Proceedings 2015 9(Suppl 9):P50

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Real-time monitoring of the physiological state of CHO cells in bioreactor by using a dual spectroscopic strategy

Authors: Franck Courtès, Bruno Ebel, Emmanuel Guedon and Annie Marc

Citation: BMC Proceedings 2015 9(Suppl 9):P48

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Recent developments in scaling down and using single use probes for measuring the live cell concentration by dielectric spectroscopy

Authors: John Carvell, Matthew Lee and Aditya R Bhat

Citation: BMC Proceedings 2015 9(Suppl 9):P46

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Model-based strategy for cell culture seed train layout verified at lab scale

Authors: Simon Kern, Oscar B Platas, Martin Schaletzky, Volker Sandig, Björn Frahm and Ralf Pörtner

Citation: BMC Proceedings 2015 9(Suppl 9):P44

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Model-based DoE for feed batch cultivation of a CHO cell line

Authors: Johannes Möllerl, Regine Eibl, Dieter Eibl and Ralf Pörtner

Citation: BMC Proceedings 2015 9(Suppl 9):P42

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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High-titer expression of recombinant antibodies by transiently transfected HEK 293-6E cell cultures

Authors: Volker Jäger, Johanna Groenewold, Dominik Krüger, Dennis Schwarz and Veith Vollmer

Citation: BMC Proceedings 2015 9(Suppl 9):P40

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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The potential of small molecules to modulate glycosylation by media design

Authors: David Brühlmann, Anaïs Muhr, Jürgen Hemberger, Markus Sauer, Henri Kornmann, Martin Jordan and Hervé Broly

Citation: BMC Proceedings 2015 9(Suppl 9):P38

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Influence of cell culture media and feed supplements on cell metabolism and quality of IgG produced in CHO-K1, CHO-S, and CHO-DG44

Authors: David Reinhart, Lukas Damjanovic, Wolfgang Sommeregger, Andreas Gili, Stanislaus Schafellner, Andreas Castan, Christian Kaisermayer and Renate Kunert

Citation: BMC Proceedings 2015 9(Suppl 9):P36

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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From Clone Selection to 80L Bioreactor Production: Better, Faster, Leaner

Authors: Marie-Françoise Clincke, Frédéric Delouvroy, Guillaume L Révérend, Jimmy Stofferis, Matthew Hinchliffe and Laetitia Malphettes

Citation: BMC Proceedings 2015 9(Suppl 9):P34

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Monitorization of pH and OTR using a multiple shake flask platform: A tool for metabolism and cell growth assessment in mammalian cell cultures

Authors: Leticia Liste-Calleja, Tibor Anderlei, Jonatan López-Repullo, Adrián Urbano, Martí Lecina and Jordi J Cairó

Citation: BMC Proceedings 2015 9(Suppl 9):P32

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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A novel measuring chamber and automation platform for mammalian cell culture processes

Authors: Tim H Lücking, Christoph Busse, Christian Lüder, David Bulnes-Abundis, Dörte Solle and Thomas Scheper

Citation: BMC Proceedings 2015 9(Suppl 9):P30

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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An improved model framework linking the extracellular environment to antibody glycosylation

Authors: Philip M Jedrzejewski, Karen M Polizzi and Cleo Kontoravdi

Citation: BMC Proceedings 2015 9(Suppl 9):P28

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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A novel low-parameter computational model to aid in-silico glycoengineering

Authors: Philipp N Spahn, Anders H Hansen, Henning G Hansen, Johnny Arnsdorf, Helene F Kildegaard and Nathan E Lewis

Citation: BMC Proceedings 2015 9(Suppl 9):P26

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Antibody disulfide bond reduction during process development: Insights using a scale-down model process

Authors: Julie Ruaudel, Martin Bertschinger, Sonia Letestu, Roberto Giovannini, Paul Wassmann and Pierre Moretti

Citation: BMC Proceedings 2015 9(Suppl 9):P24

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Optimization and scale-up of cell culture and purification processes for production of an adenovirus-based tuberculosis vaccine

Authors: Chun F Shen, Danielle Jacob, Zhongqi Shao, Alice Bernier, Xuefeng Yu, Mehul Patel, Tao Zhu and Amine Kamen

Citation: BMC Proceedings 2015 9(Suppl 9):P23

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Protection of bioreactor culture from virus contamination by use of a virus barrier filter

Authors: Kimberly Mann, Jon Royce, Christina Carbrello, Robert Smith, Rong-Rong Zhu, Yuanchun Zeng, Anne Leahy, Mary Priest, Ven Raman, Jayant S Nick Harrington, Scott Bliss, William Bryant, Nhung Nguyen, Soleil Le, Danielle DeCesaro, Jeremy Perreault…

Citation: BMC Proceedings 2015 9(Suppl 9):P22

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Host cell protein platform assay development for therapeutic mAb bioprocessing using mammalian cells

Authors: Nadine Kochanowski, Gaetan Siriez, Larissa Mukankurayija, Aurélie Delangle, Alex Murray-Smith, Kevin Dromer, David Mainwaring, Clemens Stilling, Nadja Prang, Laetitia Malphettes and Annick Gervais

Citation: BMC Proceedings 2015 9(Suppl 9):P21

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Integrating skin and vasculature in a Multi-Organ-Chip Platform

Authors: Katharina Schimek, Annina Markhoff, Frank Sonntag, Martin Blechert, Roland Lauster, Uwe Marx and Gerd Lindner

Citation: BMC Proceedings 2015 9(Suppl 9):P20

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Reconciling pillars of transient gene expression: From DNA prep via media, reagent and cell line development to holistic process optimization

Authors: Sebastian Püngel, Miklos Veiczi, Tim F Beckmann, Vanessa Vater, Penélope V Soto, Renée Ermerling, Derek Levison, Christoph Heinrich and Tim Welsink

Citation: BMC Proceedings 2015 9(Suppl 9):P18

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Technology toolbox for cell line development - next generation cell line development technologies

Authors: Holger Laux, Ursula Bodendorf, Sandrine Romand, Anett Ritter, Thomas Jostock and Burkhard Wilms

Citation: BMC Proceedings 2015 9(Suppl 9):P17

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Purification of modified vaccinia virus Ankara from suspension cell culture

Authors: Ingo Jordan, Diana Weimer, Stefan Iarusso, Holger Bernhardt, Verena Lohr and Volker Sandig

Citation: BMC Proceedings 2015 9(Suppl 9):O13

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Generation and characterization of a superior host cell line for biomanufacturing

Authors: Anett Ritter, Johannes Wienberg, Bernd Voedisch, Burkhard Wilms, Sabine Geisse, Thomas Jostock and Holger Laux

Citation: BMC Proceedings 2015 9(Suppl 9):P13

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Development of a mammalian cell culture process for rapid Clinical-Scale production of novel Influenza Nanoparticle vaccines

Authors: Payal Biswas, Christian Trozado, James Lee and Richard M Schwartz

Citation: BMC Proceedings 2015 9(Suppl 9):O12

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Protein aerosol for intranasal nose to brain (N2B) delivery

Authors: Martina Stützle, Stefan Carle, Lucas Engelhardt, Ulrich Simon, Annette Schafmeister, Chrystelle Mavoungou and Katharina Schindowski

Citation: BMC Proceedings 2015 9(Suppl 9):O11

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Increased antibody productivity in Chinese Hamster Ovary cells through induction of chromosomal instability by cell fusion

Authors: YuanShan Lai, Noriko Yamano, Masayoshi Onitsuka and Takeshi Omasa

Citation: BMC Proceedings 2015 9(Suppl 9):P11

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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RNAi-mediated knockdown of Dnmt3a enhances antibody titer in CHO cells up to 200 percent

Authors: Anica Schmidt, Anna Wippermann, Raimund Hoffrogge and Thomas Noll

Citation: BMC Proceedings 2015 9(Suppl 9):P8

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Multi-omics approach for comparative studies of monoclonal antibody producing CHO cells

Authors: Camila A Orellana, Esteban Marcellin, Trent Munro, Peter P Gary and Lars K Nielsen

Citation: BMC Proceedings 2015 9(Suppl 9):O8

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Process parameters impacting product quality

Authors: Jan Bechmann, Frederik Rudolph, Lucy Gebert, Jochen Schaub, Benedikt Greulich, Michael Dieterle and Harald Bradl

Citation: BMC Proceedings 2015 9(Suppl 9):O7

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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miR-92a enhances recombinant protein productivity in CHO cells by increasing intracellular cholesterol levels

Authors: Wan P Loh, Yuan S Yang, Andy Tan and Kong P Lam

Citation: BMC Proceedings 2015 9(Suppl 9):P6

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Understanding the impact of different bioprocess conditions on monoclonal antibody glycosylation in CHO cell cultures through experimental and computational analyses

Authors: Si N Sou, Christopher Sellick, Ken Lee, Alison Mason, Sarantos Kyriakopoulos, Karen M Polizzi and Cleo Kontoravdi

Citation: BMC Proceedings 2015 9(Suppl 9):O6

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Non-fucose level as a function of glycoenzyme transcription in a glycoengineered CHO cell line

Authors: Sven Markert, Harald Wizemann and Christine Jung

Citation: BMC Proceedings 2015 9(Suppl 9):O5

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Use of a new genetic element to improve expression level of cell lines for recombinant protein production

Authors: Emilie Vaxelaire, Lauriane Gamand, Christel Aebischer-Gumy, Pierre Moretti and Martin Bertschinger

Citation: BMC Proceedings 2015 9(Suppl 9):P4

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Production of IgGs with a human-like sialylation in CHO cells

Authors: Céline Raymond, Anna Robotham, Maureen Spearman, Michael Butler, John Kelly and Yves Durocher

Citation: BMC Proceedings 2015 9(Suppl 9):O3

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Construction of a gene knockout CHO cell line using a simple gene targeting method

Authors: Marina Aga, Noriko Yamano, Toshitaka Kumamoto, Jana Frank, Masayoshi Onitsuka and Takeshi Omasa

Citation: BMC Proceedings 2015 9(Suppl 9):P2

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Stability difference of each chromosome in Chinese Hamster Ovary cell line

Authors: Noriko Yamano, Toshitaka Kumamoto, Mai Takahashi, Jana Frank, Masayoshi Onitsuka and Takeshi Omasa

Citation: BMC Proceedings 2015 9(Suppl 9):P1

Content type: Poster presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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Front-line of genome editing technology for animal cell engineering

Authors: Tetsushi Sakuma

Citation: BMC Proceedings 2015 9(Suppl 9):O1

Content type: Oral presentation Published on: 14 December 2015

This article is part of a Supplement: Volume 9 Supplement 9
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