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  1. Nearly half of adults in the United States who are diagnosed with hypertension use blood-pressure-lowering medications. Yet there is a large interindividual variability in the response to these medications. Tw...

    Authors: Lindsay Fernández-Rhodes, Chani J. Hodonsky, Mariaelisa Graff, Shelly-Ann M. Love, Annie Green Howard, Amanda A. Seyerle, Christy L. Avery, Geetha Chittoor, Nora Franceschini, V. Saroja Voruganti, Kristin Young, Jeffrey R. O’Connell, Kari E. North and Anne E. Justice
    Citation: BMC Proceedings 2016 10(Suppl 7):65
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  2. In this study, the effects of (a) the minor allele frequency of the single nucleotide variant (SNV), (b) the degree of departure from normality of the trait, and (c) the position of the SNVs on type I error ra...

    Authors: Tae-Hwi Schwantes-An, Heejong Sung, Jeremy A. Sabourin, Cristina M. Justice, Alexa J. M. Sorant and Alexander F. Wilson
    Citation: BMC Proceedings 2016 10(Suppl 7):62
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  3. Next-generation sequencing technology makes directly testing rare variants possible. However, existing statistical methods to detect common variants may not be optimal for testing rare variants because of alle...

    Authors: Xuexia Wang, Xingwang Zhao and Jin Zhou
    Citation: BMC Proceedings 2016 10(Suppl 7):61
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  4. Genome-wide microarray expression is a rich source of functional genomic data. We examined evidence for differences in expression from peripheral blood mononuclear cells between individuals, examined some of f...

    Authors: Michael Gallaugher, Angelo J. Canty and Andrew D. Paterson
    Citation: BMC Proceedings 2016 10(Suppl 7):58
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  5. There is great interindividual variation in systolic blood pressure (SBP) as a result of the influences of several factors, including sex, ancestry, smoking status, medication use, and, especially, age. The ma...

    Authors: Anne E. Justice, Annie Green Howard, Geetha Chittoor, Lindsay Fernandez-Rhodes, Misa Graff, V. Saroja Voruganti, Guoqing Diao, Shelly-Ann M. Love, Nora Franceschini, Jeffrey R. O’Connell, Christy L. Avery, Kristin L. Young and Kari E. North
    Citation: BMC Proceedings 2016 10(Suppl 7):56
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  6. It is essential to develop adequate statistical methods to fully utilize information from longitudinal family studies. We extend our previous multipoint linkage disequilibrium approach—simultaneously accountin...

    Authors: Yen-Feng Chiu, Chun-Yi Lee and Fang-Chi Hsu
    Citation: BMC Proceedings 2016 10(Suppl 7):54
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  7. We propose a novel LASSO (least absolute shrinkage and selection operator) penalized regression method used to analyze samples consisting of (potentially) related individuals. Developed in the context of linea...

    Authors: Charalampos Papachristou, Carole Ober and Mark Abney
    Citation: BMC Proceedings 2016 10(Suppl 7):53
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  8. Current findings from genetic studies of complex human traits often do not explain a large proportion of the estimated variation of these traits due to genetic factors. This could be, in part, due to overly st...

    Authors: Emily R. Holzinger, Silke Szymczak, James Malley, Elizabeth W. Pugh, Hua Ling, Sean Griffith, Peng Zhang, Qing Li, Cheryl D. Cropp and Joan E. Bailey-Wilson
    Citation: BMC Proceedings 2016 10(Suppl 7):52
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  9. Statistical association tests for rare variants can be classified as the burden approach and the sequence kernel association test (SKAT) approach. The burden and SKAT approaches, originally developed for case–...

    Authors: Peng-Lin Lin, Wei-Yun Tsai and Ren-Hua Chung
    Citation: BMC Proceedings 2016 10(Suppl 7):47
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  10. Estimating relationships among subjects in a sample, within family structures or caused by population substructure, is complicated in admixed populations. Inaccurate allele frequencies can bias both kinship es...

    Authors: Elizabeth M. Blue, Lisa A. Brown, Matthew P. Conomos, Jennifer L. Kirk, Alejandro Q. Nato Jr, Alice B. Popejoy, Jesse Raffa, John Ranola, Ellen M. Wijsman and Timothy Thornton
    Citation: BMC Proceedings 2016 10(Suppl 7):42
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  11. The relationship between genetic variability and individual phenotypes is usually investigated by testing for association relying on called genotypes. Allele counts obtained from next-generation sequence data ...

    Authors: Rosa González Silos, Özge Karadag, Barbara Peil, Christine Fischer, Maria Kabisch, Carine Legrand and Justo Lorenzo Bermejo
    Citation: BMC Proceedings 2016 10(Suppl 7):41
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  12. With the advance of next-generation sequencing technologies, the study of rare variants in targeted genome regions or even the whole genome becomes feasible. Nevertheless, the massive amount of sequencing data...

    Authors: Xiaoran Tong, Changshuai Wei and Qing Lu
    Citation: BMC Proceedings 2016 10(Suppl 7):36
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  13. For a better understanding of the biological mechanisms involved in complex traits or diseases, networks are often useful tools in genetic studies: coexpression networks based on pairwise correlations between ...

    Authors: Renaud Tissier, Hae-Won Uh, Erik van den Akker, Brunilda Balliu, Spyridoula Tsonaka and Jeanine Houwing-Duistermaat
    Citation: BMC Proceedings 2016 10(Suppl 7):35
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  14. We propose a new method for identifying disease-related regions of single nucleotide variants in recently admixed populations. We use principal component analysis to derive both global and local ancestry infor...

    Authors: Jonathan Auerbach, Michael Agne, Rachel Fan, Adeline Lo, Shaw-Hwa Lo, Tian Zheng and Pei Wang
    Citation: BMC Proceedings 2016 10(Suppl 7):32
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  15. Expression quantitative trait locus (eQTL) maps are considered a valuable resource in studying complex diseases. The availability of gene expression data from the Genetic Analysis Workshop 19 (GAW19) provides ...

    Authors: Achilleas N. Pitsillides, Seung-Hoan Choi, John D. Hogan, Jaeyoung Hong and Honghuang Lin
    Citation: BMC Proceedings 2016 10(Suppl 7):31
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  16. The application of pathway and gene-set based analyses to high-throughput data is increasingly common and represents an effort to understand underlying biology where single-gene or single-marker analyses have ...

    Authors: Ellen E. Quillen, John Blangero and Laura Almasy
    Citation: BMC Proceedings 2016 10(Suppl 7):29
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  17. We investigate the possible replication of “known” associated single-nucleotide polymorphisms (SNPs) with blood pressure and expression phenotypes. Previous studies have provided a list of 95 SNPs thought to b...

    Authors: Richard A. J. Howey, Jakris Eu-ahsunthornwattana, Rebecca Darlay and Heather J. Cordell
    Citation: BMC Proceedings 2016 10(Suppl 7):28
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  19. Genetic association studies aim to test for disease or trait association with genetic variants, either throughout the human genome or in regions of interest. However, for most diseases and traits, the combined...

    Authors: Yen-Yi Ho, Weihua Guan, Michael O’Connell and Saonli Basu
    Citation: BMC Proceedings 2016 10(Suppl 7):26
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  20. It has been repeatedly stressed that family-based samples suffer less from genetic heterogeneity and that association analyses with family-based samples are expected to be powerful for detecting susceptibility...

    Authors: Longfei Wang, Sungkyoung Choi, Sungyoung Lee, Taesung Park and Sungho Won
    Citation: BMC Proceedings 2016 10(Suppl 7):25
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  21. Both population-based and family-based designs are commonly used in genetic association studies to identify rare variants that underlie complex diseases. For any type of study design, the statistical power wil...

    Authors: Huanhuan Zhu, Zhenchuan Wang, Xuexia Wang and Qiuying Sha
    Citation: BMC Proceedings 2016 10(Suppl 7):22
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  22. Genetic Analysis Workshop 19 provided a platform for developing and evaluating statistical methods to analyze whole-genome sequence and gene expression data from a pedigree-based sample, as well as whole-exome...

    Authors: Corinne D. Engelman, Celia M. T. Greenwood, Julia N. Bailey, Rita M. Cantor, Jack W. Kent Jr, Inke R. König, Justo Lorenzo Bermejo, Phillip E. Melton, Stephanie A. Santorico, Arne Schillert, Ellen M. Wijsman, Jean W. MacCluer and Laura Almasy
    Citation: BMC Proceedings 2016 10(Suppl 7):19
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  23. Statistical association studies are an important tool in detecting novel disease genes. However, for sequencing data, association studies confront the challenge of low power because of relatively small data sa...

    Authors: Dongni Zhang, Hongzhu Cui, Dmitry Korkin and Zheyang Wu
    Citation: BMC Proceedings 2016 10(Suppl 7):18
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  24. The aggregation of functionally associated variants given a priori biological information can aid in the discovery of rare variants associated with complex diseases. Many methods exist that aggregate rare vari...

    Authors: Alessandra Valcarcel, Kelsey Grinde, Kaitlyn Cook, Alden Green and Nathan Tintle
    Citation: BMC Proceedings 2016 10(Suppl 7):16
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  25. Large-scale sequencing studies often measure many related phenotypes in addition to the genetic variants. Joint analysis of multiple phenotypes in genetic association studies may increase power to detect disea...

    Authors: Jianping Sun, Sahir R. Bhatnagar, Karim Oualkacha, Antonio Ciampi and Celia M. T. Greenwood
    Citation: BMC Proceedings 2016 10(Suppl 7):14
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  26. A statistical departure from Mendel’s law of segregation is known as transmission ratio distortion. Although well documented in many other organisms, the extent of transmission ratio distortion and its influen...

    Authors: Sahir R. Bhatnagar, Celia M. T. Greenwood and Aurélie Labbe
    Citation: BMC Proceedings 2016 10(Suppl 7):12
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  27. Pedigree genome-wide association studies (GWAS) (Option 29) in the current version of the Mendel software is an optimized subroutine for performing large-scale genome-wide quantitative trait locus (QTL) analys...

    Authors: Hua Zhou, Jin Zhou, Tao Hu, Eric M. Sobel and Kenneth Lange
    Citation: BMC Proceedings 2016 10(Suppl 7):10
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  28. With the rapidly decreasing cost of the next-generation sequencing technology, a large number of whole genome sequences have been generated, enabling researchers to survey rare variants in the protein-coding a...

    Authors: Taebeom Kim and Peng Wei
    Citation: BMC Proceedings 2016 10(Suppl 7):9
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  29. In the past few years, imputation approaches have been mainly used in population-based designs of genome-wide association studies, although both family- and population-based imputation methods have been propos...

    Authors: Mohamad Saad, Alejandro Q. Nato Jr, Fiona L. Grimson, Steven M. Lewis, Lisa A. Brown, Elizabeth M. Blue, Timothy A. Thornton, Elizabeth A. Thompson and Ellen M. Wijsman
    Citation: BMC Proceedings 2016 10(Suppl 7):7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  30. Availability of genomic sequence data provides opportunities to study the role of low-frequency and rare variants in the etiology of complex disease. In this study, we conduct association analyses of hypertens...

    Authors: Ji-Hyung Shin, Ruiyang Yi and Shelley B. Bull
    Citation: BMC Proceedings 2016 10(Suppl 7):39
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 10 Supplement 7

  31. The Research Investments in Global Health (ResIn, www.​researchinvestme​nts.​org) study analyses funding trends in health research, with a predominant focus on ...

    Authors: Michael G. Head and Rebecca J. Brown
    Citation: BMC Proceedings 2016 10(Suppl 8):59
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 10 Supplement 8

  32. An international conference titled “Transforming Health Care in Remote Communities” was held at the Chateau Lacombe Hotel in Edmonton, Canada, April 28–30, 2016. The event was organized by the University of Al...

    Authors: T. Kue Young, Susan Chatwood, James Ford, Gwen Healey, Michael Jong, Josée Lavoie and Mason White
    Citation: BMC Proceedings 2016 10(Suppl 6):6
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 10 Supplement 6

  33. I1 Introduction and aims of the workshop

    Authors: Christa Scheidt-Nave, Thomas Ziese, Judith Fuchs, Dietrich Plass, Tom Achoki, Katherine Leach-Kemon, Peter Speyer, William E. Heisel, Emmanuela Gakidou, Theo Vos, Mohammad Hossein Forouzanfar, Jürgen C. Schmidt, Claudia E. Stein, Christa Scheidt-Nave, Elena von der Lippe, Benjamin Barnes…
    Citation: BMC Proceedings 2016 10(Suppl 5):5
    Content type: Meeting Abstracts Published on:

    This article is part of a Supplement: Volume 10 Supplement 5

  34. O1: Assessing the protective effect of dexrazoxane against doxorubicin-induced toxicity in HL-1 cardiomyocytes

    Authors: Yvonne Sweeney, Hugh O’Neill, Garry Duffy, Daniel Creegan, Viviana Bustos, Brian J. Harvey, Alexander Dalphy, Anthony O’Grady, Elaine Kay, Katarzyna Samelska, Justyna Izdebska, Anna Kurowska, Rena Al-Zubaidy, Magdalena Mroz, Brian Harvey, Ryan Fagan…
    Citation: BMC Proceedings 2016 10(Suppl 4):4
    Content type: Meeting abstracts Published on:

    This article is part of a Supplement: Volume 10 Supplement 4

  35. Over the past 30 years, dialectical behavior therapy has been shown to be an effective treatment for adult borderline personality disorder. The adaptation of DBT for adolescents (DBT-A) in different patient gr...

    Authors: Florian Hammerle, Arne Bürger, Michael Kaess and David R. Kolar
    Citation: BMC Proceedings 2016 10(Suppl 3):3
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 10 Supplement 3

  36. I1 The 9th Annual Dubai Medical Education Symposium 2015 addresses the recent strides in medical education and clinical practice

    Authors: Fouzia Shersad, Hajer Sheikh, Munther I. Aldoori, Mohammed Galal El Din Ahmed, Joseph Michael Muscat-Baron, Dima Abdelmannan, Hossam Hamdy, Syed Tanzeem Haider Raza, Parveen J. Kumar, Fatheia Ali Bayoumy, Gloria Pelizzo, Mike Irani, Fouzia Shersad, Doaa Sultan, Sumaiah Ali Abdulwahab, Tahra AlMahmoud…
    Citation: BMC Proceedings 2016 10(Suppl 2):2
    Content type: Meeting Abstracts Published on:

    This article is part of a Supplement: Volume 10 Supplement 2

  37. A1 Hope and despair in the current treatment of nasopharyngeal cancer

    Authors: IB Tan, Ellen T. Chang, Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien, Allan Hildesheim, James D. McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena Devi, L. Li…
    Citation: BMC Proceedings 2016 10(Suppl 1):1
    Content type: Meeting Abstracts Published on:

    This article is part of a Supplement: Volume 10 Supplement 1

  38. Strengthening capacity in poorer countries to generate multi-disciplinary health research and to utilise research findings, is one of the most effective ways of advancing the countries' health and development....

    Authors: Imelda Bates
    Citation: BMC Proceedings 2015 9(Suppl 10):S9
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

  39. Universal health coverage is gaining momentum and is likely to form a core part of the post Millennium Development Goal (MDG) agenda and be linked to social determinants of health, including gender;

    Authors: Sally Theobald, Eleanor MacPherson, Rosalind McCollum and Rachel Tolhurst
    Citation: BMC Proceedings 2015 9(Suppl 10):S8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

  40. Achieving the 2020 goals for Neglected Tropical Diseases (NTDs) requires scale-up of Mass Drug Administration (MDA) which will require long-term commitment of national and global financing partners, strengthen...

    Authors: Eleanor E Macpherson, Emily R Adams, Moses J Bockarie, T Deirdre Hollingsworth, Louise A Kelly-Hope, Mike Lehane, Vanja Kovacic, Robert A Harrison, Mark JI Paine, Lisa J Reimer and Stephen J Torr
    Citation: BMC Proceedings 2015 9(Suppl 10):S7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

  41. Most neglected tropical diseases (NTDs) have complex life cycles and are challenging to control. The “2020 goals” of control and elimination as a public health programme for a number of NTDs are the subject of...

    Authors: T Deirdre Hollingsworth, Ivor Langley, D James Nokes, Eleanor E Macpherson, Gerry McGivern, Emily R Adams, Moses J Bockarie, Kevin Mortimer, Lisa J Reimer, Bertie Squire, Stephen J Torr and Graham F Medley
    Citation: BMC Proceedings 2015 9(Suppl 10):S6
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

  42. Priorities for NTD control programmes will shift over the next 10-20 years as the elimination phase reaches the ‘end game’ for some NTDs, and the recognition that the control of other NTDs is much more problem...

    Authors: Lisa J Reimer, Emily R Adams, Mark JI Paine, Hilary Ranson, Marlize Coleman, Edward K Thomsen, Eleanor E MacPherson, T Deirdre Hollingsworth, Louise A Kelly-Hope, Moses J Bockarie, Louise Ford, Robert A Harrison, J Russell Stothard, Mark J Taylor, Nicholas Hamon and Stephen J Torr
    Citation: BMC Proceedings 2015 9(Suppl 10):S5
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

  43. Costs incurred during care-seeking for chronic respiratory disease are a major problem with severe consequences for socio-economic status and health outcomes. Most of the published evidence to date relates to ...

    Authors: SB Squire, Rachael Thomson, Ireen Namakhoma, Asma El Sony, Afranio Kritski and Jason Madan
    Citation: BMC Proceedings 2015 9(Suppl 10):S4
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

  44. Chronic respiratory symptoms are amongst the most common complaints among low and middle-income country (LMICs) populations and they are expected to remain common over the 10 to 20 year horizon. The underlying...

    Authors: Kevin Mortimer, Luis Cuevas, Bertie Squire, Rachael Thomson and Rachel Tolhurst
    Citation: BMC Proceedings 2015 9(Suppl 10):S3
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

  45. The overall aim of the 2014 Consultation is to bring together internal and external partners to help shape the strategic direction for CAHRD over the 10 to 20 year horizon. Our strategic thinking will be guide...

    Authors: SB Squire
    Citation: BMC Proceedings 2015 9(Suppl 10):S2
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 9 Supplement 10

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